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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2011 | 22 | A+ | CAR | CLE | 3 | 2 | .600 | 0 | 15 | 15 | 0 | 0 | 0 | 77.0 | 56 | 22 | 16 | 2 | 32 | 0 | 95 | 1 | 0 | 1.87 | 1.14 | | 2011 | 22 | AA | TEX | COL | 1 | 0 | 1.000 | 0 | 2 | 2 | 0 | 0 | 0 | 10.0 | 2 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 0.00 | 0.20 | | 2011 | 22 | AA | EAS | CLE | 0 | 1 | .000 | 0 | 3 | 3 | 0 | 0 | 0 | 14.0 | 10 | 4 | 4 | 1 | 6 | 0 | 17 | 0 | 0 | 2.57 | 1.14 | | 2011 | 22 | MLB | NL | COL | 2 | 1 | .667 | 0 | 4 | 4 | 0 | 0 | 0 | 18.1 | 19 | 11 | 11 | 0 | 5 | 0 | 13 | 1 | 2 | 5.40 | 1.31 | | 2012 | 23 | AA | TEX | COL | 0 | 0 | --- | 0 | 1 | 1 | 0 | 0 | 0 | 4.0 | 4 | 0 | 0 | 0 | 1 | 0 | 4 | 1 | 0 | 0.00 | 1.25 | | 2012 | 23 | AAA | PCL | COL | 4 | 4 | .500 | 0 | 9 | 9 | 0 | 0 | 0 | 46.2 | 52 | 23 | 13 | 2 | 20 | 0 | 46 | 0 | 0 | 2.51 | 1.54 | | 2012 | 23 | MLB | NL | COL | 2 | 9 | .182 | 0 | 22 | 22 | 0 | 0 | 0 | 96.2 | 97 | 57 | 53 | 14 | 46 | 2 | 83 | 4 | 4 | 4.93 | 1.48 | | 2013 | 24 | AA | TEX | COL | 0 | 1 | .000 | 0 | 1 | 1 | 0 | 0 | 0 | 5.0 | 10 | 7 | 7 | 2 | 1 | 0 | 5 | 0 | 0 | 12.60 | 2.20 | | 2013 | 24 | AAA | PCL | COL | 8 | 1 | .889 | 0 | 15 | 15 | 0 | 0 | 0 | 85.2 | 83 | 40 | 40 | 6 | 33 | 0 | 96 | 3 | 0 | 4.20 | 1.35 | | 2013 | 24 | MLB | NL | COL | 0 | 4 | .000 | 0 | 8 | 4 | 0 | 0 | 0 | 21.2 | 25 | 15 | 15 | 4 | 19 | 1 | 19 | 1 | 5 | 6.23 | 2.03 | | 2014 | 25 | AAA | PCL | OAK | 3 | 1 | .750 | 0 | 8 | 8 | 0 | 0 | 0 | 46.1 | 45 | 19 | 19 | 6 | 17 | 1 | 54 | 0 | 0 | 3.69 | 1.34 | | 2014 | 25 | MLB | AL | OAK | 5 | 4 | .556 | 0 | 20 | 10 | 4 | 0 | 0 | 69.0 | 51 | 22 | 18 | 7 | 26 | 0 | 64 | 1 | 10 | 2.35 | 1.12 | | 2015 | 26 | A+ | CAL | OAK | 0 | 0 | --- | 0 | 1 | 0 | 0 | 0 | 0 | 2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0.00 | 0.00 | | 2015 | 26 | MLB | AL | OAK | 5 | 6 | .455 | 3 | 53 | 9 | 9 | 0 | 0 | 86.0 | 71 | 44 | 35 | 8 | 31 | 1 | 82 | 3 | 8 | 3.66 | 1.19 | | 2016 | 27 | MLB | NL | SD | 8 | 7 | .533 | 0 | 17 | 17 | 0 | 0 | 0 | 102.0 | 67 | 30 | 28 | 8 | 41 | 2 | 115 | 1 | 4 | 2.47 | 1.06 | | 2016 | 27 | MLB | AL | BOS | 3 | 5 | .375 | 0 | 14 | 13 | 1 | 0 | 0 | 68.2 | 70 | 35 | 35 | 14 | 24 | 1 | 71 | 0 | 6 | 4.59 | 1.37 | | 2016 | 27 | MLB | | TOT | 11 | 12 | .478 | 0 | 31 | 30 | 1 | 0 | 0 | 170.2 | 137 | 65 | 63 | 22 | 65 | 3 | 186 | 1 | 10 | 3.32 | 1.18 | | 2017 | 28 | MLB | AL | BOS | 17 | 6 | .739 | 0 | 32 | 32 | 0 | 0 | 0 | 173.2 | 166 | 69 | 64 | 19 | 68 | 0 | 174 | 4 | 23 | 3.32 | 1.35 | | 2018 | 29 | AA | EAS | | 1 | 0 | 1.000 | 0 | 1 | 1 | 0 | 0 | 0 | 5.0 | 4 | 2 | 2 | 1 | 3 | 0 | 4 | 0 | 0 | 3.60 | 1.40 | | 2018 | 29 | AAA | INT | | 0 | 2 | .000 | 0 | 5 | 5 | 0 | 0 | 0 | 19.1 | 16 | 12 | 12 | 7 | 13 | 0 | 12 | 0 | 0 | 5.59 | 1.50 | | 2018 | 29 | MLB | AL | BOS | 2 | 6 | .250 | 0 | 26 | 11 | 5 | 0 | 0 | 74.0 | 87 | 53 | 50 | 12 | 44 | 1 | 66 | 4 | 9 | 6.08 | 1.77 | | 2019 | 30 | MLB | NL | SF | 2 | 9 | .182 | 0 | 21 | 17 | 0 | 0 | 0 | 77.2 | 89 | 51 | 49 | 17 | 36 | 0 | 92 | 4 | 5 | 5.68 | 1.61 | | 2019 | 30 | MLB | NL | MIL | 0 | 1 | .000 | 2 | 25 | 1 | 4 | 0 | 0 | 26.1 | 16 | 7 | 7 | 4 | 8 | 0 | 45 | 0 | 2 | 2.39 | 0.91 | | 2019 | 30 | MLB | NL | TOT | 2 | 10 | .167 | 2 | 46 | 18 | 4 | 0 | 0 | 104.0 | 105 | 58 | 56 | 21 | 44 | 0 | 137 | 4 | 7 | 4.85 | 1.43 | | 2020 | 31 | MLB | NL | SD | 1 | 0 | 1.000 | 4 | 20 | 0 | 5 | 0 | 0 | 18.2 | 9 | 3 | 3 | 1 | 10 | 0 | 29 | 0 | 2 | 1.45 | 1.02 | | 2021 | 32 | MLB | NL | SD | 1 | 0 | 1.000 | 0 | 27 | 0 | 2 | 0 | 0 | 25.2 | 19 | 6 | 5 | 2 | 10 | 1 | 30 | 0 | 3 | 1.75 | 1.13 | | 2025 | 36 | MLB | NL | CHN | 2 | 2 | .500 | 1 | 57 | 4 | 11 | 0 | 0 | 49.2 | 38 | 14 | 12 | 5 | 15 | 1 | 57 | 5 | 3 | 2.17 | 1.07 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 20 | 12 | .625 | 0 | 61 | 60 | 0 | 0 | 0 | 315.0 | 282 | 129 | 113 | 27 | 126 | 1 | 343 | 5 | 0 | 3.23 | 1.30 | | Career | COL | 4 | 14 | .222 | 0 | 34 | 30 | 0 | 0 | 0 | 136.2 | 141 | 83 | 79 | 18 | 70 | 3 | 115 | 6 | 11 | 5.20 | 1.54 | | Career | OAK | 10 | 10 | .500 | 3 | 73 | 19 | 13 | 0 | 0 | 155.0 | 122 | 66 | 53 | 15 | 57 | 1 | 146 | 4 | 18 | 3.08 | 1.15 | | Career | SD | 10 | 7 | .588 | 4 | 64 | 17 | 7 | 0 | 0 | 146.1 | 95 | 39 | 36 | 11 | 61 | 3 | 174 | 1 | 9 | 2.21 | 1.07 | | Career | BOS | 22 | 17 | .564 | 0 | 72 | 56 | 6 | 0 | 0 | 316.1 | 323 | 157 | 149 | 45 | 136 | 2 | 311 | 8 | 38 | 4.24 | 1.45 | | Career | SF | 2 | 9 | .182 | 0 | 21 | 17 | 0 | 0 | 0 | 77.2 | 89 | 51 | 49 | 17 | 36 | 0 | 92 | 4 | 5 | 5.68 | 1.61 | | Career | MIL | 0 | 1 | .000 | 2 | 25 | 1 | 4 | 0 | 0 | 26.1 | 16 | 7 | 7 | 4 | 8 | 0 | 45 | 0 | 2 | 2.39 | 0.91 | | Career | CHN | 2 | 2 | .500 | 1 | 57 | 4 | 11 | 0 | 0 | 49.2 | 38 | 14 | 12 | 5 | 15 | 1 | 57 | 5 | 3 | 2.17 | 1.07 | | Career | Majors | 50 | 60 | .455 | 10 | 346 | 144 | 41 | 0 | 0 | 908.0 | 824 | 417 | 385 | 115 | 383 | 10 | 940 | 28 | 86 | 3.82 | 1.33 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2011 | 22 | MLB | NL | COL | | | | | | | | | | 2.1 | 2 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 3.86 | 0.86 | | 2011 | 22 | MLB | NL | COL | | | | | | | | | | 16.0 | 17 | 10 | 10 | 0 | 5 | 0 | 12 | 0 | 2 | 5.63 | 1.38 | | 2012 | 23 | MLB | NL | COL | | | | | | | | | | 25.0 | 14 | 6 | 5 | 1 | 8 | 0 | 30 | 1 | 1 | 1.80 | 0.88 | | 2012 | 23 | MLB | NL | COL | | | | | | | | | | 71.2 | 83 | 51 | 48 | 13 | 38 | 2 | 53 | 3 | 3 | 6.03 | 1.69 | | 2013 | 24 | MLB | NL | COL | | | | | | | | | | 7.0 | 3 | 2 | 2 | 0 | 3 | 0 | 10 | 0 | 1 | 2.57 | 0.86 | | 2013 | 24 | MLB | NL | COL | | | | | | | | | | 14.2 | 22 | 13 | 13 | 4 | 16 | 1 | 9 | 1 | 4 | 7.98 | 2.59 | | 2014 | 25 | MLB | AL | OAK | | | | | | | | | | 15.0 | 13 | 5 | 4 | 2 | 6 | 0 | 17 | 0 | 1 | 2.40 | 1.27 | | 2014 | 25 | MLB | AL | OAK | | | | | | | | | | 54.0 | 38 | 17 | 14 | 5 | 20 | 0 | 47 | 1 | 9 | 2.33 | 1.07 | | 2015 | 26 | MLB | AL | OAK | | | | | | | | | | 29.2 | 15 | 8 | 7 | 2 | 7 | 0 | 33 | 2 | 3 | 2.12 | 0.74 | | 2015 | 26 | MLB | AL | OAK | | | | | | | | | | 56.1 | 56 | 36 | 28 | 6 | 24 | 1 | 49 | 1 | 5 | 4.47 | 1.42 | | 2016 | 27 | MLB | | TOT | | | | | | | | | | 44.1 | 40 | 13 | 12 | 2 | 19 | 1 | 42 | 0 | 3 | 2.44 | 1.33 | | 2016 | 27 | MLB | | TOT | | | | | | | | | | 126.1 | 97 | 52 | 51 | 20 | 46 | 2 | 144 | 1 | 7 | 3.63 | 1.13 | | 2017 | 28 | MLB | AL | BOS | | | | | | | | | | 35.2 | 43 | 19 | 18 | 3 | 14 | 0 | 47 | 4 | 1 | 4.54 | 1.60 | | 2017 | 28 | MLB | AL | BOS | | | | | | | | | | 138.0 | 123 | 50 | 46 | 16 | 54 | 0 | 127 | 0 | 22 | 3.00 | 1.28 | | 2018 | 29 | MLB | AL | BOS | | | | | | | | | | 16.2 | 18 | 11 | 9 | 0 | 5 | 0 | 11 | 3 | 4 | 4.86 | 1.38 | | 2018 | 29 | MLB | AL | BOS | | | | | | | | | | 57.1 | 69 | 42 | 41 | 12 | 39 | 1 | 55 | 1 | 5 | 6.44 | 1.88 | | 2019 | 30 | MLB | | TOT | | | | | | | | | | 32.2 | 28 | 15 | 15 | 5 | 7 | 0 | 45 | 1 | 1 | 4.13 | 1.07 | | 2019 | 30 | MLB | | TOT | | | | | | | | | | 71.1 | 77 | 43 | 41 | 16 | 37 | 0 | 92 | 3 | 6 | 5.17 | 1.60 | | 2020 | 31 | MLB | NL | SD | | | | | | | | | | 4.1 | 2 | 0 | 0 | 0 | 2 | 0 | 6 | 0 | 1 | 0.00 | 0.92 | | 2020 | 31 | MLB | NL | SD | | | | | | | | | | 14.1 | 7 | 3 | 3 | 1 | 8 | 0 | 23 | 0 | 1 | 1.88 | 1.05 | | 2021 | 32 | MLB | NL | SD | | | | | | | | | | 9.1 | 5 | 2 | 2 | 0 | 3 | 0 | 14 | 0 | 0 | 1.93 | 0.86 | | 2021 | 32 | MLB | NL | SD | | | | | | | | | | 16.1 | 14 | 4 | 3 | 2 | 7 | 1 | 16 | 0 | 3 | 1.65 | 1.29 | | 2025 | 36 | MLB | NL | CHN | | | | | | | | | | 20.2 | 13 | 6 | 4 | 0 | 5 | 0 | 28 | 1 | 1 | 1.74 | 0.87 | | 2025 | 36 | MLB | NL | CHN | | | | | | | | | | 29.0 | 25 | 8 | 8 | 5 | 10 | 1 | 29 | 4 | 2 | 2.48 | 1.21 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 242.2 | 196 | 88 | 79 | 15 | 79 | 1 | 284 | 13 | 17 | 2.93 | 1.13 | | Career | vs RH | | | | | | | | | | 665.1 | 628 | 329 | 306 | 100 | 304 | 9 | 656 | 15 | 69 | 4.14 | 1.40 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2011 | 22 | MLB | NL | COL | 4 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | .200 | .200 | .200 | .400 | | 2012 | 23 | AA | TEX | COL | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .500 | .500 | .500 | 1.000 | | 2012 | 23 | AAA | PCL | COL | 9 | 10 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | .200 | .200 | .200 | .400 | | 2012 | 23 | MLB | NL | COL | 22 | 26 | 2 | 6 | 2 | 0 | 1 | 1 | 1 | 0 | 15 | 0 | 0 | 4 | 0 | 0 | 1 | .231 | .259 | .423 | .682 | | 2013 | 24 | AAA | PCL | COL | 15 | 21 | 1 | 6 | 1 | 0 | 0 | 3 | 1 | 0 | 8 | 0 | 0 | 2 | 1 | 0 | 0 | .286 | .304 | .333 | .638 | | 2013 | 24 | MLB | NL | COL | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2016 | 27 | MLB | NL | SD | 17 | 33 | 2 | 5 | 0 | 0 | 1 | 4 | 0 | 0 | 19 | 0 | 0 | 2 | 0 | 0 | 1 | .152 | .152 | .242 | .394 | | 2016 | 27 | MLB | AL | BOS | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2016 | 27 | MLB | | TOT | 18 | 35 | 2 | 5 | 0 | 0 | 1 | 4 | 0 | 0 | 21 | 0 | 0 | 2 | 0 | 0 | 1 | .143 | .143 | .229 | .371 | | 2017 | 28 | MLB | AL | BOS | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2019 | 30 | MLB | NL | SF | 14 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13 | 0 | 0 | 1 | 0 | 0 | 1 | .000 | .000 | .000 | .000 | | 2019 | 30 | MLB | NL | MIL | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2019 | 30 | MLB | NL | TOT | 15 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13 | 0 | 0 | 1 | 0 | 0 | 1 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Minors | Minors | 25 | 33 | 1 | 9 | 1 | 0 | 0 | 4 | 1 | 0 | 13 | 0 | 0 | 3 | 1 | 0 | 0 | .273 | .286 | .303 | .589 | | Career | COL | 30 | 34 | 2 | 7 | 2 | 0 | 1 | 1 | 1 | 0 | 19 | 0 | 0 | 7 | 0 | 0 | 1 | .206 | .229 | .353 | .582 | | Career | SD | 17 | 33 | 2 | 5 | 0 | 0 | 1 | 4 | 0 | 0 | 19 | 0 | 0 | 2 | 0 | 0 | 1 | .152 | .152 | .242 | .394 | | Career | BOS | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | SF | 14 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13 | 0 | 0 | 1 | 0 | 0 | 1 | .000 | .000 | .000 | .000 | | Career | MIL | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | Majors | 64 | 89 | 4 | 12 | 2 | 0 | 2 | 5 | 1 | 0 | 54 | 0 | 0 | 10 | 0 | 0 | 3 | .135 | .144 | .225 | .369 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2011 | 22 | MLB | NL | COL | | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2011 | 22 | MLB | NL | COL | | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | .500 | .500 | .500 | 1.000 | | 2012 | 23 | MLB | NL | COL | | 7 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | .429 | .429 | .571 | 1.000 | | 2012 | 23 | MLB | NL | COL | | 19 | 2 | 3 | 1 | 0 | 1 | 1 | 1 | 0 | 11 | 0 | 0 | 3 | 0 | 0 | 1 | .158 | .200 | .368 | .568 | | 2013 | 24 | MLB | NL | COL | | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2013 | 24 | MLB | NL | COL | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2016 | 27 | MLB | | TOT | | 17 | 2 | 5 | 0 | 0 | 1 | 4 | 0 | 0 | 7 | 0 | 0 | 1 | 0 | 0 | 1 | .294 | .294 | .471 | .765 | | 2016 | 27 | MLB | | TOT | | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2017 | 28 | MLB | AL | BOS | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2017 | 28 | MLB | AL | BOS | | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2019 | 30 | MLB | | TOT | | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2019 | 30 | MLB | | TOT | | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 1 | 0 | 0 | 1 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Career | vs LH | | 36 | 2 | 8 | 1 | 0 | 1 | 4 | 0 | 0 | 19 | 0 | 0 | 4 | 0 | 0 | 1 | .222 | .222 | .333 | .556 | | Career | vs RH | | 53 | 2 | 4 | 1 | 0 | 1 | 1 | 1 | 0 | 35 | 0 | 0 | 6 | 0 | 0 | 2 | .075 | .093 | .151 | .244 |
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