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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2012 | 18 | R | GCL | BAL | 2 | 0 | 1.000 | 2 | 12 | 0 | 6 | 0 | 0 | 20.1 | 12 | 7 | 6 | 2 | 7 | 0 | 35 | 2 | 0 | 2.66 | 0.93 | | 2012 | 18 | A- | NYP | BAL | 0 | 0 | --- | 0 | 5 | 0 | 0 | 0 | 0 | 8.0 | 2 | 0 | 0 | 0 | 2 | 0 | 13 | 1 | 0 | 0.00 | 0.50 | | 2013 | 19 | A | MWL | HOU | 2 | 0 | 1.000 | 0 | 5 | 5 | 0 | 0 | 0 | 22.1 | 14 | 8 | 8 | 0 | 12 | 0 | 16 | 4 | 0 | 3.22 | 1.16 | | 2013 | 19 | A | SAL | BAL | 3 | 6 | .333 | 0 | 17 | 17 | 0 | 0 | 0 | 85.0 | 67 | 41 | 25 | 4 | 42 | 0 | 79 | 6 | 0 | 2.65 | 1.28 | | 2014 | 20 | A+ | CAL | HOU | 9 | 2 | .818 | 2 | 22 | 15 | 3 | 0 | 0 | 103.0 | 76 | 41 | 31 | 9 | 38 | 1 | 112 | 10 | 0 | 2.71 | 1.11 | | 2014 | 20 | AA | TEX | HOU | 1 | 1 | .500 | 0 | 5 | 4 | 0 | 0 | 0 | 20.0 | 16 | 14 | 14 | 2 | 16 | 0 | 24 | 3 | 0 | 6.30 | 1.60 | | 2015 | 21 | AA | TEX | HOU | 3 | 3 | .500 | 1 | 17 | 10 | 2 | 0 | 0 | 65.0 | 60 | 31 | 23 | 5 | 24 | 0 | 69 | 4 | 0 | 3.18 | 1.29 | | 2015 | 21 | AA | SOU | MIL | 1 | 4 | .200 | 0 | 7 | 7 | 0 | 0 | 0 | 38.2 | 27 | 13 | 12 | 3 | 11 | 0 | 50 | 3 | 0 | 2.79 | 0.98 | | 2016 | 22 | AA | SOU | MIL | 2 | 1 | .667 | 0 | 11 | 11 | 0 | 0 | 0 | 57.0 | 38 | 7 | 6 | 1 | 19 | 0 | 73 | 3 | 0 | 0.95 | 1.00 | | 2016 | 22 | AAA | PCL | MIL | 1 | 7 | .125 | 0 | 14 | 14 | 0 | 0 | 0 | 69.0 | 63 | 42 | 40 | 5 | 36 | 0 | 88 | 3 | 0 | 5.22 | 1.43 | | 2017 | 23 | AAA | PCL | | 3 | 4 | .429 | 0 | 12 | 12 | 0 | 0 | 0 | 52.0 | 49 | 32 | 31 | 14 | 31 | 0 | 51 | 0 | 0 | 5.37 | 1.54 | | 2017 | 23 | MLB | NL | MIL | 2 | 3 | .400 | 0 | 35 | 0 | 2 | 0 | 0 | 47.2 | 25 | 11 | 11 | 4 | 22 | 1 | 68 | 4 | 4 | 2.08 | 0.99 | | 2018 | 24 | MLB | NL | MIL | 6 | 1 | .857 | 12 | 55 | 0 | 14 | 0 | 0 | 81.1 | 36 | 23 | 22 | 9 | 30 | 0 | 143 | 1 | 1 | 2.43 | 0.81 | | 2019 | 25 | MLB | NL | MIL | 3 | 5 | .375 | 37 | 61 | 0 | 46 | 0 | 0 | 75.2 | 41 | 24 | 22 | 15 | 20 | 2 | 138 | 4 | 2 | 2.62 | 0.81 | | 2020 | 26 | MLB | NL | MIL | 1 | 2 | .333 | 13 | 21 | 0 | 17 | 0 | 0 | 19.0 | 8 | 8 | 8 | 3 | 10 | 0 | 31 | 3 | 0 | 3.79 | 0.95 | | 2021 | 27 | MLB | NL | MIL | 4 | 2 | .667 | 34 | 60 | 0 | 42 | 0 | 0 | 58.2 | 25 | 8 | 8 | 3 | 24 | 0 | 102 | 2 | 2 | 1.23 | 0.84 | | 2022 | 28 | MLB | NL | MIL | 1 | 4 | .200 | 29 | 37 | 0 | 34 | 0 | 0 | 34.0 | 26 | 16 | 16 | 7 | 12 | 0 | 59 | 1 | 0 | 4.24 | 1.12 | | 2022 | 28 | MLB | NL | SD | 1 | 1 | .500 | 7 | 19 | 0 | 11 | 0 | 0 | 16.0 | 17 | 14 | 13 | 1 | 9 | 0 | 22 | 3 | 0 | 7.31 | 1.63 | | 2022 | 28 | MLB | NL | TOT | 2 | 5 | .286 | 36 | 56 | 0 | 45 | 0 | 0 | 50.0 | 43 | 30 | 29 | 8 | 21 | 0 | 81 | 4 | 0 | 5.22 | 1.28 | | 2023 | 29 | MLB | NL | SD | 2 | 3 | .400 | 33 | 61 | 0 | 52 | 0 | 0 | 56.1 | 32 | 11 | 8 | 3 | 30 | 2 | 85 | 3 | 3 | 1.28 | 1.10 | | 2024 | 30 | MLB | AL | HOU | 8 | 8 | .500 | 34 | 71 | 0 | 62 | 0 | 0 | 71.0 | 43 | 33 | 30 | 12 | 25 | 0 | 105 | 1 | 5 | 3.80 | 0.96 | | 2025 | 31 | MLB | AL | HOU | 6 | 2 | .750 | 28 | 48 | 0 | 41 | 0 | 0 | 52.2 | 29 | 16 | 12 | 8 | 16 | 1 | 76 | 2 | 0 | 2.05 | 0.85 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 27 | 28 | .491 | 5 | 127 | 95 | 11 | 0 | 0 | 540.1 | 424 | 236 | 196 | 45 | 238 | 1 | 610 | 39 | 0 | 3.26 | 1.23 | | Career | MIL | 17 | 17 | .500 | 125 | 269 | 0 | 155 | 0 | 0 | 316.1 | 161 | 90 | 87 | 41 | 118 | 3 | 541 | 15 | 9 | 2.48 | 0.88 | | Career | SD | 3 | 4 | .429 | 40 | 80 | 0 | 63 | 0 | 0 | 72.1 | 49 | 25 | 21 | 4 | 39 | 2 | 107 | 6 | 3 | 2.61 | 1.22 | | Career | HOU | 14 | 10 | .583 | 62 | 119 | 0 | 103 | 0 | 0 | 123.2 | 72 | 49 | 42 | 20 | 41 | 1 | 181 | 3 | 5 | 3.06 | 0.91 | | Career | Majors | 34 | 31 | .523 | 227 | 468 | 0 | 321 | 0 | 0 | 512.1 | 282 | 164 | 150 | 65 | 198 | 6 | 829 | 24 | 17 | 2.64 | 0.94 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2017 | 23 | MLB | NL | MIL | | | | | | | | | | 17.0 | 8 | 3 | 3 | 0 | 12 | 0 | 31 | 1 | 0 | 1.59 | 1.18 | | 2017 | 23 | MLB | NL | MIL | | | | | | | | | | 30.2 | 17 | 8 | 8 | 4 | 10 | 1 | 37 | 3 | 4 | 2.35 | 0.88 | | 2018 | 24 | MLB | NL | MIL | | | | | | | | | | 27.2 | 8 | 4 | 4 | 1 | 11 | 0 | 49 | 0 | 0 | 1.30 | 0.69 | | 2018 | 24 | MLB | NL | MIL | | | | | | | | | | 53.2 | 28 | 19 | 18 | 8 | 19 | 0 | 94 | 1 | 1 | 3.02 | 0.88 | | 2019 | 25 | MLB | NL | MIL | | | | | | | | | | 18.0 | 9 | 6 | 6 | 5 | 2 | 0 | 34 | 1 | 0 | 3.00 | 0.61 | | 2019 | 25 | MLB | NL | MIL | | | | | | | | | | 57.2 | 32 | 18 | 16 | 10 | 18 | 2 | 104 | 3 | 2 | 2.50 | 0.87 | | 2020 | 26 | MLB | NL | MIL | | | | | | | | | | 3.2 | 2 | 1 | 1 | 1 | 3 | 0 | 6 | 0 | 0 | 2.45 | 1.36 | | 2020 | 26 | MLB | NL | MIL | | | | | | | | | | 15.1 | 6 | 7 | 7 | 2 | 7 | 0 | 25 | 3 | 0 | 4.11 | 0.85 | | 2021 | 27 | MLB | NL | MIL | | | | | | | | | | 13.0 | 6 | 1 | 1 | 0 | 5 | 0 | 23 | 0 | 0 | 0.69 | 0.85 | | 2021 | 27 | MLB | NL | MIL | | | | | | | | | | 45.2 | 19 | 7 | 7 | 3 | 19 | 0 | 79 | 2 | 2 | 1.38 | 0.83 | | 2022 | 28 | MLB | | TOT | | | | | | | | | | 12.0 | 9 | 7 | 7 | 1 | 5 | 0 | 23 | 0 | 0 | 5.25 | 1.17 | | 2022 | 28 | MLB | | TOT | | | | | | | | | | 38.0 | 34 | 23 | 22 | 7 | 16 | 0 | 58 | 4 | 0 | 5.21 | 1.32 | | 2023 | 29 | MLB | NL | SD | | | | | | | | | | 10.2 | 9 | 1 | 1 | 0 | 6 | 0 | 16 | 0 | 0 | 0.84 | 1.41 | | 2023 | 29 | MLB | NL | SD | | | | | | | | | | 45.2 | 23 | 10 | 7 | 3 | 24 | 2 | 69 | 3 | 3 | 1.38 | 1.03 | | 2024 | 30 | MLB | AL | HOU | | | | | | | | | | 14.2 | 6 | 6 | 4 | 0 | 5 | 0 | 22 | 0 | 1 | 2.45 | 0.75 | | 2024 | 30 | MLB | AL | HOU | | | | | | | | | | 56.1 | 37 | 27 | 26 | 12 | 20 | 0 | 83 | 1 | 4 | 4.15 | 1.01 | | 2025 | 31 | MLB | AL | HOU | | | | | | | | | | 11.2 | 8 | 6 | 3 | 2 | 2 | 0 | 16 | 0 | 0 | 2.31 | 0.86 | | 2025 | 31 | MLB | AL | HOU | | | | | | | | | | 41.0 | 21 | 10 | 9 | 6 | 14 | 1 | 60 | 2 | 0 | 1.98 | 0.85 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 128.1 | 65 | 35 | 30 | 10 | 51 | 0 | 220 | 2 | 1 | 2.10 | 0.90 | | Career | vs RH | | | | | | | | | | 384.0 | 217 | 129 | 120 | 55 | 147 | 6 | 609 | 22 | 16 | 2.81 | 0.95 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2015 | 21 | AA | SOU | MIL | 7 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2017 | 23 | AAA | PCL | | 8 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | .083 | .083 | .083 | .167 | | 2017 | 23 | MLB | NL | MIL | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2018 | 24 | MLB | NL | MIL | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .500 | .500 | .500 | 1.000 | | 2019 | 25 | MLB | NL | MIL | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Minors | Minors | 15 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | .045 | .045 | .045 | .091 | | Career | MIL | 8 | 8 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | .125 | .125 | .125 | .250 | | Career | Majors | 8 | 8 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | .125 | .125 | .125 | .250 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2017 | 23 | MLB | NL | MIL | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2017 | 23 | MLB | NL | MIL | | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2018 | 24 | MLB | NL | MIL | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2018 | 24 | MLB | NL | MIL | | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .500 | .500 | .500 | 1.000 | | 2019 | 25 | MLB | NL | MIL | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2019 | 25 | MLB | NL | MIL | | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Career | vs LH | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | Career | vs RH | | 8 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | .125 | .125 | .125 | .250 |
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