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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2008 | 21 | R | PIO | LAN | 3 | 0 | 1.000 | 9 | 21 | 2 | 18 | 0 | 0 | 30.0 | 22 | 14 | 8 | 1 | 17 | 0 | 37 | 0 | 0 | 2.40 | 1.30 | | 2009 | 22 | A | MWL | LAN | 5 | 3 | .625 | 5 | 34 | 0 | 15 | 0 | 0 | 71.0 | 68 | 27 | 23 | 5 | 15 | 1 | 55 | 1 | 0 | 2.92 | 1.17 | | 2009 | 22 | A+ | CAR | WAS | 1 | 0 | 1.000 | 0 | 2 | 0 | 0 | 0 | 0 | 4.0 | 0 | 0 | 0 | 0 | 1 | 0 | 7 | 0 | 0 | 0.00 | 0.25 | | 2010 | 23 | A | SAL | WAS | 4 | 4 | .500 | 0 | 26 | 0 | 5 | 0 | 0 | 51.0 | 48 | 25 | 22 | 3 | 17 | 1 | 43 | 5 | 0 | 3.88 | 1.27 | | 2010 | 23 | A+ | CAR | WAS | 0 | 0 | --- | 0 | 6 | 0 | 1 | 0 | 0 | 8.1 | 21 | 17 | 10 | 0 | 10 | 0 | 3 | 0 | 0 | 10.80 | 3.72 | | 2013 | 26 | A+ | FSL | PHI | 0 | 1 | .000 | 7 | 14 | 0 | 10 | 0 | 0 | 19.1 | 15 | 3 | 3 | 2 | 5 | 0 | 20 | 1 | 0 | 1.40 | 1.03 | | 2013 | 26 | AA | EAS | PHI | 2 | 1 | .667 | 1 | 11 | 0 | 8 | 0 | 0 | 11.0 | 10 | 3 | 3 | 1 | 3 | 0 | 13 | 0 | 0 | 2.45 | 1.18 | | 2013 | 26 | AAA | INT | PHI | 0 | 0 | --- | 3 | 8 | 0 | 6 | 0 | 0 | 11.0 | 5 | 1 | 1 | 0 | 4 | 0 | 8 | 0 | 0 | 0.82 | 0.82 | | 2013 | 26 | MLB | NL | PHI | 1 | 1 | .500 | 0 | 24 | 0 | 6 | 0 | 0 | 31.1 | 27 | 15 | 13 | 3 | 23 | 0 | 23 | 1 | 6 | 3.73 | 1.60 | | 2014 | 27 | AAA | INT | PHI | 2 | 1 | .667 | 22 | 39 | 0 | 35 | 0 | 0 | 46.2 | 35 | 8 | 5 | 0 | 16 | 1 | 52 | 1 | 0 | 0.96 | 1.09 | | 2014 | 27 | MLB | NL | PHI | 1 | 0 | 1.000 | 0 | 13 | 0 | 5 | 0 | 0 | 14.0 | 14 | 12 | 10 | 2 | 13 | 0 | 12 | 0 | 1 | 6.43 | 1.93 | | 2015 | 28 | MLB | NL | PHI | 4 | 6 | .400 | 2 | 72 | 0 | 14 | 0 | 0 | 66.2 | 72 | 28 | 26 | 4 | 37 | 8 | 63 | 0 | 9 | 3.51 | 1.64 | | 2016 | 29 | AAA | INT | PHI | 6 | 3 | .667 | 13 | 48 | 0 | 26 | 0 | 0 | 54.2 | 38 | 13 | 13 | 3 | 24 | 0 | 53 | 5 | 0 | 2.14 | 1.13 | | 2016 | 29 | MLB | NL | PHI | 1 | 1 | .500 | 0 | 17 | 0 | 7 | 0 | 0 | 15.1 | 21 | 11 | 11 | 2 | 8 | 1 | 14 | 1 | 0 | 6.46 | 1.89 | | 2017 | 30 | AAA | INT | | 0 | 0 | --- | 1 | 4 | 1 | 1 | 0 | 0 | 4.2 | 5 | 3 | 3 | 0 | 5 | 1 | 7 | 0 | 0 | 5.79 | 2.14 | | 2017 | 30 | MLB | NL | PHI | 2 | 5 | .286 | 2 | 66 | 0 | 16 | 0 | 0 | 71.1 | 61 | 22 | 21 | 3 | 26 | 5 | 60 | 0 | 8 | 2.65 | 1.22 | | 2018 | 31 | AA | EAS | | 0 | 1 | .000 | 0 | 1 | 0 | 0 | 0 | 0 | 0.2 | 3 | 2 | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 27.00 | 4.50 | | 2018 | 31 | AAA | INT | | 0 | 0 | --- | 0 | 2 | 0 | 0 | 0 | 0 | 1.1 | 3 | 2 | 2 | 1 | 0 | 0 | 3 | 0 | 0 | 13.50 | 2.25 | | 2018 | 31 | MLB | NL | PHI | 3 | 1 | .750 | 1 | 59 | 0 | 7 | 0 | 0 | 46.0 | 49 | 31 | 31 | 4 | 18 | 1 | 51 | 4 | 5 | 6.07 | 1.46 | | 2019 | 32 | A+ | CAL | | 0 | 0 | --- | 0 | 1 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0.00 | 0.00 | | 2019 | 32 | MLB | AL | LAA | 2 | 1 | .667 | 1 | 64 | 2 | 18 | 0 | 0 | 62.0 | 61 | 35 | 30 | 13 | 33 | 1 | 57 | 5 | 9 | 4.35 | 1.52 | | 2020 | 33 | MLB | AL | TEX | 0 | 2 | .000 | 0 | 11 | 2 | 3 | 0 | 0 | 8.1 | 10 | 9 | 7 | 1 | 9 | 1 | 11 | 0 | 1 | 7.56 | 2.28 | | 2021 | 34 | MLB | NL | STL | 1 | 1 | .500 | 2 | 34 | 0 | 6 | 0 | 0 | 33.1 | 25 | 12 | 12 | 2 | 8 | 1 | 34 | 1 | 0 | 3.24 | 0.99 | | 2022 | 35 | MLB | NL | SD | 4 | 6 | .400 | 3 | 64 | 0 | 11 | 0 | 0 | 61.0 | 57 | 28 | 23 | 3 | 17 | 0 | 68 | 5 | 7 | 3.39 | 1.21 | | 2023 | 36 | MLB | NL | SD | 2 | 3 | .400 | 0 | 61 | 0 | 26 | 0 | 0 | 59.2 | 59 | 30 | 27 | 6 | 24 | 1 | 53 | 6 | 4 | 4.07 | 1.39 | | 2024 | 37 | MLB | AL | LAA | 5 | 1 | .833 | 4 | 45 | 0 | 8 | 0 | 0 | 43.2 | 37 | 21 | 18 | 4 | 14 | 1 | 40 | 3 | 4 | 3.71 | 1.17 | | 2024 | 37 | MLB | AL | BOS | 0 | 0 | --- | 0 | 15 | 0 | 2 | 0 | 0 | 15.1 | 24 | 15 | 14 | 4 | 1 | 1 | 13 | 0 | 0 | 8.22 | 1.63 | | 2024 | 37 | MLB | AL | TOT | 5 | 1 | .833 | 4 | 60 | 0 | 10 | 0 | 0 | 59.0 | 61 | 36 | 32 | 8 | 15 | 2 | 53 | 3 | 4 | 4.88 | 1.29 | | 2025 | 38 | MLB | NL | LAN | 2 | 0 | 1.000 | 0 | 28 | 0 | 12 | 0 | 0 | 27.1 | 34 | 17 | 16 | 1 | 16 | 4 | 24 | 0 | 5 | 5.27 | 1.83 | | 2025 | 38 | MLB | NL | WAS | 0 | 0 | --- | 0 | 10 | 0 | 1 | 0 | 0 | 10.0 | 5 | 1 | 1 | 1 | 2 | 0 | 7 | 0 | 4 | 0.90 | 0.70 | | 2025 | 38 | MLB | AL | LAA | 0 | 2 | .000 | 2 | 20 | 0 | 2 | 0 | 0 | 18.0 | 16 | 5 | 4 | 0 | 8 | 1 | 17 | 0 | 5 | 2.00 | 1.33 | | 2025 | 38 | MLB | NL | TOT | 2 | 0 | 1.000 | 0 | 38 | 0 | 13 | 0 | 0 | 37.1 | 39 | 18 | 17 | 2 | 18 | 4 | 31 | 0 | 9 | 4.10 | 1.53 | | 2025 | 38 | MLB | | TOT | 2 | 2 | .500 | 2 | 58 | 0 | 15 | 0 | 0 | 55.1 | 55 | 23 | 21 | 2 | 26 | 5 | 48 | 0 | 14 | 3.42 | 1.46 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Minors | Minors | 23 | 14 | .622 | 61 | 217 | 3 | 125 | 0 | 0 | 314.2 | 273 | 118 | 95 | 18 | 117 | 4 | 305 | 13 | 0 | 2.72 | 1.24 | | Career | PHI | 12 | 14 | .462 | 5 | 251 | 0 | 55 | 0 | 0 | 244.2 | 244 | 119 | 112 | 18 | 125 | 15 | 223 | 6 | 29 | 4.12 | 1.51 | | Career | LAA | 7 | 4 | .636 | 7 | 129 | 2 | 28 | 0 | 0 | 123.2 | 114 | 61 | 52 | 17 | 55 | 3 | 114 | 8 | 18 | 3.78 | 1.37 | | Career | TEX | 0 | 2 | .000 | 0 | 11 | 2 | 3 | 0 | 0 | 8.1 | 10 | 9 | 7 | 1 | 9 | 1 | 11 | 0 | 1 | 7.56 | 2.28 | | Career | STL | 1 | 1 | .500 | 2 | 34 | 0 | 6 | 0 | 0 | 33.1 | 25 | 12 | 12 | 2 | 8 | 1 | 34 | 1 | 0 | 3.24 | 0.99 | | Career | SD | 6 | 9 | .400 | 3 | 125 | 0 | 37 | 0 | 0 | 120.2 | 116 | 58 | 50 | 9 | 41 | 1 | 121 | 11 | 11 | 3.73 | 1.30 | | Career | BOS | 0 | 0 | --- | 0 | 15 | 0 | 2 | 0 | 0 | 15.1 | 24 | 15 | 14 | 4 | 1 | 1 | 13 | 0 | 0 | 8.22 | 1.63 | | Career | LAN | 2 | 0 | 1.000 | 0 | 28 | 0 | 12 | 0 | 0 | 27.1 | 34 | 17 | 16 | 1 | 16 | 4 | 24 | 0 | 5 | 5.27 | 1.83 | | Career | WAS | 0 | 0 | --- | 0 | 10 | 0 | 1 | 0 | 0 | 10.0 | 5 | 1 | 1 | 1 | 2 | 0 | 7 | 0 | 4 | 0.90 | 0.70 | | Career | Majors | 28 | 30 | .483 | 17 | 603 | 4 | 144 | 0 | 0 | 583.1 | 572 | 292 | 264 | 53 | 257 | 26 | 547 | 26 | 68 | 4.07 | 1.42 |
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| Year | Age | Lvl | Lg | Org | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| 2013 | 26 | MLB | NL | PHI | | | | | | | | | | 12.1 | 9 | 7 | 7 | 1 | 9 | 0 | 10 | 1 | 4 | 5.11 | 1.46 | | 2013 | 26 | MLB | NL | PHI | | | | | | | | | | 19.0 | 18 | 8 | 6 | 2 | 14 | 0 | 13 | 0 | 2 | 2.84 | 1.68 | | 2014 | 27 | MLB | NL | PHI | | | | | | | | | | 8.2 | 6 | 7 | 6 | 1 | 5 | 0 | 7 | 0 | 1 | 6.23 | 1.27 | | 2014 | 27 | MLB | NL | PHI | | | | | | | | | | 5.1 | 8 | 5 | 4 | 1 | 8 | 0 | 5 | 0 | 0 | 6.75 | 3.00 | | 2015 | 28 | MLB | NL | PHI | | | | | | | | | | 24.1 | 35 | 12 | 10 | 2 | 17 | 7 | 22 | 0 | 4 | 3.70 | 2.14 | | 2015 | 28 | MLB | NL | PHI | | | | | | | | | | 42.1 | 37 | 16 | 16 | 2 | 20 | 1 | 41 | 0 | 5 | 3.40 | 1.35 | | 2016 | 29 | MLB | NL | PHI | | | | | | | | | | 8.0 | 14 | 8 | 8 | 1 | 2 | 1 | 6 | 1 | 0 | 9.00 | 2.00 | | 2016 | 29 | MLB | NL | PHI | | | | | | | | | | 7.1 | 7 | 3 | 3 | 1 | 6 | 0 | 8 | 0 | 0 | 3.68 | 1.77 | | 2017 | 30 | MLB | NL | PHI | | | | | | | | | | 31.0 | 35 | 14 | 14 | 2 | 14 | 5 | 20 | 0 | 3 | 4.06 | 1.58 | | 2017 | 30 | MLB | NL | PHI | | | | | | | | | | 40.1 | 26 | 8 | 7 | 1 | 12 | 0 | 40 | 0 | 5 | 1.56 | 0.94 | | 2018 | 31 | MLB | NL | PHI | | | | | | | | | | 18.1 | 21 | 9 | 9 | 1 | 7 | 1 | 18 | 0 | 3 | 4.42 | 1.53 | | 2018 | 31 | MLB | NL | PHI | | | | | | | | | | 27.2 | 28 | 22 | 22 | 3 | 11 | 0 | 33 | 4 | 2 | 7.16 | 1.41 | | 2019 | 32 | MLB | AL | LAA | | | | | | | | | | 26.0 | 26 | 19 | 15 | 5 | 19 | 0 | 25 | 0 | 4 | 5.19 | 1.73 | | 2019 | 32 | MLB | AL | LAA | | | | | | | | | | 36.0 | 35 | 16 | 15 | 8 | 14 | 1 | 32 | 5 | 5 | 3.75 | 1.36 | | 2020 | 33 | MLB | AL | TEX | | | | | | | | | | 4.0 | 7 | 3 | 3 | 1 | 3 | 1 | 5 | 0 | 1 | 6.75 | 2.50 | | 2020 | 33 | MLB | AL | TEX | | | | | | | | | | 4.1 | 3 | 6 | 4 | 0 | 6 | 0 | 6 | 0 | 0 | 8.31 | 2.08 | | 2021 | 34 | MLB | NL | STL | | | | | | | | | | 11.0 | 13 | 4 | 4 | 2 | 5 | 1 | 14 | 0 | 0 | 3.27 | 1.64 | | 2021 | 34 | MLB | NL | STL | | | | | | | | | | 22.1 | 12 | 8 | 8 | 0 | 3 | 0 | 20 | 1 | 0 | 3.22 | 0.67 | | 2022 | 35 | MLB | NL | SD | | | | | | | | | | 24.1 | 23 | 14 | 13 | 2 | 10 | 0 | 24 | 4 | 3 | 4.81 | 1.36 | | 2022 | 35 | MLB | NL | SD | | | | | | | | | | 36.2 | 34 | 14 | 10 | 1 | 7 | 0 | 44 | 1 | 4 | 2.45 | 1.12 | | 2023 | 36 | MLB | NL | SD | | | | | | | | | | 22.1 | 28 | 16 | 15 | 0 | 12 | 1 | 22 | 0 | 0 | 6.04 | 1.79 | | 2023 | 36 | MLB | NL | SD | | | | | | | | | | 37.1 | 31 | 14 | 12 | 6 | 12 | 0 | 31 | 6 | 4 | 2.89 | 1.15 | | 2024 | 37 | MLB | | TOT | | | | | | | | | | 25.0 | 26 | 14 | 13 | 3 | 10 | 2 | 25 | 2 | 2 | 4.68 | 1.44 | | 2024 | 37 | MLB | | TOT | | | | | | | | | | 34.0 | 35 | 22 | 19 | 5 | 5 | 0 | 28 | 1 | 2 | 5.03 | 1.18 | | 2025 | 38 | MLB | | TOT | | | | | | | | | | 24.1 | 22 | 9 | 7 | 0 | 14 | 5 | 20 | 0 | 8 | 2.59 | 1.48 | | 2025 | 38 | MLB | | TOT | | | | | | | | | | 31.0 | 33 | 14 | 14 | 2 | 12 | 0 | 28 | 0 | 6 | 4.06 | 1.45 | | Totals | | | | | W | L | Win% | SV | G | GS | GF | CG | ShO | IP | H | R | ER | HR | BB | IBB | SO | HB | GIDP | ERA | WHIP |
| Career | vs LH | | | | | | | | | | 239.2 | 265 | 136 | 124 | 21 | 127 | 24 | 218 | 8 | 33 | 4.66 | 1.64 | | Career | vs RH | | | | | | | | | | 343.2 | 307 | 156 | 140 | 32 | 130 | 2 | 329 | 18 | 35 | 3.67 | 1.27 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2013 | 26 | MLB | NL | PHI | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2016 | 29 | MLB | NL | PHI | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | --- | --- | --- | --- | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Career | PHI | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | Career | Majors | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 |
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| Year | Age | Lvl | Lg | Org | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| 2013 | 26 | MLB | NL | PHI | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2013 | 26 | MLB | NL | PHI | | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | .000 | .000 | .000 | | 2016 | 29 | MLB | NL | PHI | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | 2016 | 29 | MLB | NL | PHI | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | --- | --- | --- | --- | | Totals | | | | | G | AB | R | H | 2B | 3B | HR | RBI | BB | IBB | SO | SB | CS | SH | SF | HB | GIDP | BA | OBA | SLG | OPS |
| Career | vs LH | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | --- | --- | --- | --- | | Career | vs RH | | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | .000 | .000 | .000 | .000 |
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